Inhibition of Paclitaxel against Neuroglioma Cells U251 Growth and Its Mechanism
نویسندگان
چکیده
BACKGROUND Glioma is the most common primary tumor of the central nervous system, and accounted for about 70% of primary tumors. MATERIALS AND METHODS In the study, antitumour activity and mechanism of paclitaxel was investigated. Different concentrations of paclitaxel (200, 300, 400 μmol/L) was treated in neuroglioma cellsU251. RESULTS Paclitaxel significantly inhibited neuroglioma cells growth, and promoted its apoptosis. Paclitaxel can block tumour cells in the G2/M phase. In addition, apoptosis-related genes caspase-3 and bax expressions were increased after paclitaxel treatment. CONCLUSION Our work indicated that paclitaxel displayed strong anti-tumour activity.
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عنوان ژورنال:
دوره 14 شماره
صفحات -
تاریخ انتشار 2017